To better understand the available publications addressing ethical issues in rural health care we sought to identify the ethics literature that specifically focuses on rural America. We wanted to determine the extent to which the rural ethics literature was distributed between general commentaries, descriptive summaries of research, and original research publications. We identified 55 publications that specifically and substantively addressed rural health care ethics, published between 1966 and 2004. Only 7 (13%) of these publications were original research articles while (12) (...) 22% were descriptive summaries of research and 36 (65%) were general commentaries. The majority of publications examined (55%) were clinically focused while 27% addressed organizational ethics and 18% addressed ethical ramifications of rural health care policy at a national or community level. Our findings indicate that there are a limited number of publications focusing on rural health care ethics, suggesting a need for scholars and researchers to more rigorously address rural ethics issues. (shrink)

PurposeTo use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD).MethodsA vocabulary was acquired from four AMD experts who examined 100 ophthalmoscopic images. The vocabulary was analyzed, hierarchically structured, and incorporated into a collaborative computer classification system called IDOCS. Using this system, three of the experts examined images from a second set of digital images compiled from more than 1000 patients with AMD. Images (...) were annotated, and features were identified and defined. Decision trees, a machine learning method, were trained on the data collected and used to extract patterns. Interrelationships between the data from the different clinicians were investigated.ResultsSix drusen classes in the structured vocabulary were largely sufficient to describe all the identified features. The decision trees classified the data with 76.86% to 88.5% accuracy and distilled patterns in the form of hierarchical trees composed of 5 to 15 nodes. Experts were largely consistent in their characterization of soft, and to a lesser extent, hard drusen, but diverge in definition of other drusen. Size and crystalline morphology were the main determinants of drusen type across all experts.ConclusionsMachine learning is a powerful tool for the characterization of disease phenotypes. The creation of a defined feature set for AMD will facilitate the development of an IDOCS-based classification system. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

Thomas Jefferson and Philosophy: Essays on the Philosophical Cast of Jefferson’s Writings is a collection of essays on topics that relate to philosophical aspects of Jefferson’s thinking over the years. Much historical insight is given to ground the various philosophical strands in Jefferson’s thought and writing on topics such as political philosophy, moral philosophy, slavery, republicanism, wall of separation, liberty, educational philosophy, and architecture.

This book provides a unique, cogent, engaging account of environmental determinism that has long been much needed in the classroom and beyond." -- Andrew Sluyter, Associate Professor, Louisiana State University, USA This book pulls together major critiques of contemporary attempts to explain nature-society relations in an environmentally deterministic way. After defining key terms, it reviews the history of environmental determinism's rise and fall within geography in the early twentieth century. It discusses the key reasons for the doctrine's rejection and (...) presents alternative, non-deterministic frameworks developed within geography for analyzing the roles played by the environment in human affairs. The authors examine the rise in recent decades of neo-deterministic approaches to such issues as the demarcation of regions, the causes of civilizational collapse in prehistory, today's globally uneven patterns of human well-being, and the consequences of human-induced climate change. In each case, the authors draw on the insights and approaches of geography, the academic discipline most conversant with the interactions of society and environment, to challenge the widespread acceptance that such approaches have won. The book will appeal to those working on human-environmental research, international development and global policy initiatives. William B. Meyer is Associate Professor of Geography at Colgate University, USA. He is the author of several previous books, including Human Impact on the Earth, Americans and Their Weather: A History, and The Progressive Environmental Prometheans. His research interests include urban geography, environmental history, and the history of environmental thought. Dylan M.T. Guss works in the technology investment sector. (shrink)

Job 1–21: Interpretation and Commentary. By C. L. Seow. Illuminations. Grand Rapids, Mich.: William B. Eerdmans Publishing Co., 2013. Pp. xxviii + 971. $95.

H´ector-Neri Casta˜neda-Calder´on (December 13, 1924–September 7, 1991) was born in San Vicente Zacapa, Guatemala. He attended the Normal School for Boys in Guatemala City, later called the Military Normal School for Boys, from which he was expelled for refusing to fight a bully; the dramatic story, worthy of being filmed, is told in the “De Re” section of his autobiography, “Self-Profile” (1986). He then attended a normal school in Costa Rica, followed by studies in philosophy at the University of San (...) Carlos, Guatemala. He won a scholarship to the University of Minnesota, where he received his B.A. (1950), M.A. (1952), and Ph.D. (1954), all in philosophy. His dissertation, “The Logical Structure of Moral Reasoning”, was written under the direction of Wilfrid Sellars. He returned to teach in Guatemala, and then received a scholarship to study at Oxford University (1955–1956), after which he took a sabbatical-replacement position in philosophy at Duke University (1956). His first full-time academic appointment was at Wayne State University (1957– 1969), where he founded the philosophy journal Noˆus (1967, a counter-offer made to him by Wayne State to encourage him to stay there rather than to take the chairmanship of philosophy at the University of Pennsylvania). In 1969, he moved (along with several of his Wayne colleagues) to Indiana University, where he eventually became the Mahlon Powell Professor of Philosophy and, later, its first Dean of Latino Affairs (1978–1981). He remained at Indiana until his death. He was also a visiting professor of philosophy at the University of Texas at Austin (1962–1963) and a fellow at the Center for Advanced Study in the Behavioral Sciences (1981–1982). He received grants and fellowships from the Guggenheim Foundation (1967–1968), the T. Andrew Mellon Foundation, the National Endowment for the Humanities, and the National Science Foundation. He was elected President of the American Philosophical Association Central Division (1979– 1980), named to the American Academy of Arts and Sciences (1990), and received the Presidential Medal of Honor from the Government of Guatemala (1991). Casta˜neda’s philosophical interests spanned virtually the entire spectrum of philosophy, and his theories form a highly interconnected whole.. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Faulkner's Novels Past and PresentAndrew J. McKenna (bio)This article contains instances of the N-word. The Editor, Michigan State University Press, and Michigan State University do not condone the use of this word and only after careful consideration have we reprinted it. In this case, the word appears in the context of works by Faulkner.When I first came East I kept thinking You've got to remember to think of some (...) of them as coloured people not niggers, … I learned that the best way to take all people, black or white, is to take them for what they think they are, and leave them alone. That was when I realized that a nigger is not a person so much as a form of behavior; a sort of obverse reflection of the white people he lives among.—Faulkner, The Sound and the Fury ([1929] 2019, 45)A black man is a person who must ride Jim Crow in Georgia.—W. E. B. Du Bois ([1940] 1992, 153)When William Faulkner memorably stated, "the past is not dead, it's not even past," he was not reaching out for a place in the world-historical pantheon of aphoristic wisdom; he wasn't thinking about culture and history in general. A person of his own time and place, he was thinking about his experience in his own homeland, the deep South of his native [End Page 39] Mississippi, with its cherished myth of a Lost Cause that ennobled the effort to tear our country apart over slavery, and that subsequently enabled Jim Crow legislation, spawned the KKK, and sanctioned a century of lynching and burning. There has been an uptick of attention to Faulkner owing to Carl Rollyson's recent two-volume biography (2020) and, especially for my purposes, Michael Gorra's The Saddest Words: William Faulkner's Civil War (2020), which focuses on the centrality of that cataclysm in his creative imagination and his historical vision.On more than one occasion Faulkner himself was emphatic in his own ambivalence toward "his native land," as in this self-description: "He was born of it and his bones will sleep in it; loving it even while hating some of it … the intolerance and injustice; the lynching of negroes not for the crimes they committed but because their skins were black" (in Blotner 2005, 354). Gorra (2020) argues that this very ambivalence is a generative resource for the author's greatest achievements, quoting Yeats's notorious dictum, "We make out of the quarrel with others, rhetoric, but of the quarrel with ourselves, poetry" (346). This can remind us of the notorious "crucible of doubt" out of which Dostoevsky allegedly forged his fiction. The Russian novelist is named (Blotner 2005, 718) as among seven of Faulkner's "masters" in the literary education of this omnivorous autodidact, with the others being Melville, Conrad, Balzac, Flaubert, Dickens, and Cervantes. With Dostoevsky especially he shares an admixture of horror and benign good humor. On occasion Faulkner was classed as an author of Southern Gothic, a label also applied to Flannery O'Connor, who, with Toni Morrison and Cormac McCarthy, counts among his greatest literary progeny. A more capacious designation might rank him with masters of the grotesque, as Mikhail Bakhtin has explored this anomalous category in his writings on Rabelais and Dostoevsky.Light in August (Faulkner, 1932) begins and ends on a humorous note, as we follow the quest of the guileless Lena Grove for the father of her unborn child. She has concluded from her "endless care of other children" in her brother's household, "'I reckon that's why I got one so quick myself'" (3); the novel closes with her newborn infant in her arms in her now aimless trek, marveling, "My, my. A body does get around: here we aint been coming from Alabama but two months, and now it's already Tennessee" (480).Lena's peregrinations bookend the story of Joe Christmas, so named because he was born on that day and who, we find later in the narrative, was snatched away by his religiously fanatical grandfather to be placed in an orphanage, then snatched away again to be placed... (shrink)

It has become standard practice for scientists to avoid the possibility of references to God by adopting methodological naturalism, a method that assumes that the reality of the universe, as it can be accessed by empirical enquiry, is to be explained solely with recourse to natural phenomena. In this essay, I critique the Christian practice of this method, arguing that a Christian's practices should always reflect her belief that the universe is created and sustained by the triune God. This leads (...) me to contend that the Christian should adopt a theologically humble approach to the sciences, with which she humbly acknowledges that special divine action is not discernible by empirical science. To further my critique, I consider three ways in which the practice of MN can be particularly problematic for Christianity. (shrink)

This paper considers the neuropsychology of religious and spiritual experiences. This requires a review of our current understanding of brain function as well as an integrated synthesis to derive a neuropsychological model of spiritual experiences. Religious and spiritual experiences are highly complex states that likely involve many brain structures including those involved in higher order processing of sensory and cognitive input as well as those involved in the elaboration of emotions and autonomic responses. Such an analysis can help elucidate the (...) biological correlates of these experiences and provide new information regarding the function of the human brain. (shrink)

We have studied a number of long-term meditators in previous studies. The purpose of this study was to determine if there are differences in baseline brain function of experienced meditators compared to non-meditators. All subjects were recruited as part of an ongoing study of different meditation practices. We evaluated 12 advanced meditators and 14 non-meditators with cerebral blood flow SPECT imaging at rest. Images were analyzed with both region of interest and statistical parametric mapping. The CBF of long-term meditators was (...) significantly higher compared to non-meditators in the prefrontal cortex, parietal cortex, thalamus, putamen, caudate, and midbrain. There was also a significant difference in the thalamic laterality with long-term meditators having greater asymmetry. The observed changes associated with long-term meditation appear in structures that underlie the attention network and also those that relate to emotion and autonomic function. (shrink)

This article reviews and responds to various issues that have been raised in critical analysis of our work studying the relationship between religion and the brain. An adequate response necessitates a discussion about the origins of this research, the potential pitfalls of doing empirical research in this field, and the complex requirements of interpreting the implications of such an approach. Through inquiry such as this, the study of the brain and its relation to religion and religious experience will continue to (...) advance and uncover the many fascinating questions that await. (shrink)

The most comprehensive collection of its kind, this unique anthology presents fifty-four readings--many of them not widely available--by the most important and influential Christian, Jewish, and Muslim philosophers of the Middle Ages. The text is organized topically, making it easily accessible to students, and the large selection of readings provides instructors with maximum flexiblity in choosing course material. Each thematic section is comprised of six chronologically arranged readings. This organization focuses on the major philosophical issues and allows a smooth introduction (...) to the material. The topics covered are: (1) The Existence of God, (2) Ethics and the Problem of Evil, (3) God's Foreknowledge and Free Will, (4) Theology, (5) Political Philosophy, 6) Knowledge and Sensation, (7) Universals, (8) Logic and the Philosophy of Language and (9) Physics. Each text is preceded by a biographical note on the author and a brief analytical introduction. Unlike other anthologies, which present sources as a series of truncated excerpts, this collection avoids intrusive editing and includes many selections in their entirety, thus preserving the rich flavor of the medieval mind at work. (shrink)

The 2010 Quinnipiac cheerleading case raises interesting questions about the nature of both cheerleading and sport, as well as about the moral character of each. In this paper we explore some of those questions, and argue that no form of college cheerleading currently in existence deserves, from a moral point of view, to be recognized as a sport for Title IX purposes. To reach that conclusion, we evaluate cheerleading using a quasi-legal argument based on the NCAA’s definition of sport and (...) conclude that cheerleading fails to qualify as a legitimate sport. A philosophical argument leads to the same conclusion, primarily because of the essential entertainment-aspect of cheerleading. We then examine a consequentialist moral case for making cheerleading an intercollegiate sport and argue that the balance of moral reasons is against doing so. Finally, we look at cheerleading’s newest offspring – Acrobatics and Tumbling, and STUNT – and express our moral reservations about their current claims to be worthy of Title IX recognition. While we would not claim that any single one of our arguments is decisive, we are convinced that the cumulative weight of the arguments against granting intercollegiate sport status to any of the forms of cheerleading or its derivatives is, at present, irresistible. (shrink)

This article reviews the neuroscientific understanding of the self and personal identity, focusing on various elements of inclusivity and exclusivity as well as engaging religious and spiritual perspectives. We will also consider how the identity is comprised of biological, social, and ideological or spiritual aspects, and how they are interconnected. We will consider how the brain helps us to construct and maintain our representation of the self and what happens when we have self-transcendent experiences. Such an evaluation will have implications (...) for understanding the intersection between consciousness and the self. This information will be helpful from both the psychological and spiritual perspective for understanding human identity. (shrink)

: According to the long orthodox interpretation of Kant's theory of motivation, Kant recognized only two fundamental types of motives: moral motives and egoistic, hedonistic motives. Seeking to defend Kant against the ensuing charges of psychological simplism, Andrews Reath formulated a forceful and seminal repudiation of this interpretation in his 1989 essay “Hedonism, Heteronomy and Kant's Principle of Happiness.” The current paper aims to show that Reath's popular exegetical alternative is untenable. His arguments against the traditional view miss the mark, (...) and his revisionist interpretation of Kant's theory of motivation cannot bear the considerable weight of the countervailing evidence. (shrink)

This article provides a response to John Perry and Sarah Lane Ritchie's article, “Magnets Magic, and Other Anomalies: In Defense of Methodological Naturalism.” In so doing, it provides a defense of some of the arguments I made in my article, “Should a Christian Adopt Methodological Naturalism?” I begin by addressing some of the confusion about my position. However, it is not simply my intention to address confusions. There remain some fundamental differences between my position and Perry and Ritchie's. It is (...) on these differences that I wish to focus––differences that enable me to maintain my critique of methodological naturalism without falling prey to the problems they raise. Constructively, I advance the argument that the Christian scientist should be open to the possibility of theology‐engaged science, as well as the science‐engaged theology that Perry and Ritchie advocate. (shrink)

In the study of the divinization of Roman emperors, a great deal depends upon the sequence of events. According to the model of consecratio proposed by Bickermann, apotheosis was supposed to be accomplished during the deceased emperor's public funeral, after which the Senate acknowledged what had transpired by decreeing appropriate honours for the new diuus. Contradictory evidence has turned up in the Fasti Ostienses, however, which seem to indicate that both Marciana and Faustina were declared diuae before their funerals took (...) place. This suggests a shift away from the Augustan precedent, whereby the testimony of a witness had been required to establish divinity, to a procedure in which the senators were able to jump ahead to the politically foreordained conclusion and bestow the honour at once. Careful re-examination of the evidence in Tacitus and Suetonius has made it possible to assign this development to the year 54, with the consecration of Claudius. (shrink)

This article reexamines the evidence for the relationships between the Vestal virgins and their natal kin from the second century BC to the third century ad. It suggests that the bond between these priestesses and their families remained strong throughout this period and that, as a consequence, interpretations of the Vestals' position within Roman society that emphasize the severing of agnatic ties through their removal from patria potestas may be misguided. When placed in the broader social and legal context, the (...) ritual “capture” of these priestesses is shown to be a necessary feature of their priestly identity, which only marked the Vestals as extraordinary because of the unique intersection of religious and gender categories that characterized their office. Finally, the implications of these findings for the interpretation of Vestal virginity are discussed. (shrink)

In the past few decades, neuroscience research has greatly expanded our understanding of how the human brain functions. In particular, we have begun to explore the basis of emotions, intelligence, and creativity. These brain functions also have been applied to various aspects of behavior, thought, and experience. We have also begun to develop an understanding of how the brain and mind work during aesthetic and religious experiences. Studies on these topics have included neuropsychological tests, physiological measures, and brain imaging. These (...) different techniques have enabled us to open up a window into the brain. It is by understanding the functioning of the creative brain that we begin to understand the concept of the creative mind. It is through the use of emotions and other higher cognitive functions that the brain and mind can create ideas, music, literature, and ultimately our entire repertoire of behaviors. How these different creative abilities are derived can also be traced to various parts of the brain and how they function. Modern neuroscience allows us to begin to understand the creative aspect of the brain and mind and perhaps can take us one step further toward understanding the most profound types of aesthetic and religious experiences. (shrink)

In the past few decades, neuroscience research has greatly expanded our understanding of how the human brain functions. In particular, we have begun to explore the basis of emotions, intelligence, and creativity. These brain functions also have been applied to various aspects of behavior, thought, and experience. We have also begun to develop an understanding of how the brain and mind work during aesthetic and religious experiences. Studies on these topics have included neuropsychological tests, physiological measures, and brain imaging. These (...) different techniques have enabled us to open up a window into the brain. It is by understanding the functioning of the creative brain that we begin to understand the concept of the creative mind. It is through the use of emotions and other higher cognitive functions that the brain and mind can create ideas, music, literature, and ultimately our entire repertoire of behaviors. How these different creative abilities are derived can also be traced to various parts of the brain and how they function. Modern neuroscience allows us to begin to understand the creative aspect of the brain and mind and perhaps can take us one step further toward understanding the most profound types of aesthetic and religious experiences. (shrink)

The topic of "Neurotheology" has garnered increasing attention in the academic, religious, scientific, and popular worlds. However, there have been no attempts at exploring more specifically how Jewish religious thought and experience may intersect with neurotheology. The Rabbi's Brain engages this groundbreaking area. Topics included relate to a neurotheological approach to the foundational beliefs that arise from the Torah and associated scriptures, Jewish learning, an exploration of the different elements of Judaism (i.e. Reform, Conservative, and Orthodox), an exploration of specifically (...) Jewish practices (i.e. Davening, Sabbath, Kosher), and a review of Jewish mysticism. (shrink)

The topic of "Neurotheology" has garnered increasing attention in the academic, religious, scientific, and popular worlds. However, there have been no attempts at exploring more specifically how Jewish religious thought and experience may intersect with neurotheology. The Rabbi's Brain engages this groundbreaking area. Topics included relate to a neurotheological approach to the foundational beliefs that arise from the Torah and associated scriptures, Jewish learning, an exploration of the different elements of Judaism (i.e. Reform, Conservative, and Orthodox), an exploration of specifically (...) Jewish practices (i.e. Davening, Sabbath, Kosher), and a review of Jewish mysticism. (shrink)

This article argues that human flourishing is grounded in relationships of mutual judgement according to which we live and grow as characters in the stories of others. More specifically, it will make a theological case that true human flourishing emerges in a world governed by the judgement of the triune God who creates us to find fulfilment in Jesus Christ, by the Spirit, according to the will of the Father. In so doing, it contends that human flourishing is both grounded (...) in and brought about by relationships of accountability. (shrink)

Are the characteristics and relationships among spatio-temporal entities "real" or are they simply conventional terms that note similarities among things in the world but lack any reality of their own? Or if they are real, what sort of reality do they have? Do we live in a world of causes and effects, or is this relation a useful contrivance for our convenience? What is the nature of this "I" that we invoke when referring to ourselves? Is it body? Mind? Both? (...) Neither? And once its nature is understood, what can be said of the choices it makes? Are they really ours, freely made by an independent will? Or is each choice determined more by the internal makeup of the "I" we happen to be and the social/environmental circumstances in which this "I" finds itself, rather than by any act of will? But if each of us "could not have chosen otherwise" than we have, are we no better than the machines we construct? Then again, maybe some of our more advanced machines should be considered conscious entities? Introduction to Metaphysics: The Fundamental Questions presents these and other intriguing questions, many of which have challenged philosophers from antiquity to the present in their efforts to speculate on the nature of what is real. Often filled with twists and turns, dark corners and hidden recesses, this journey of discovery is an exciting excursion into the depths of human understanding. As guides for this intellectual journey editor Andrew Schoedinger has chosen an impressive array of creative and thought-provoking philosophers: Peter Abelard, Aristotle, Renford Bambrough, George Berkeley, Joseph Butler, Rudolf Carnap, Roderick Chisholm, R.G. Collingwood, Arthur Danto, Donald Davidson, Rene Descartes, C.J. Ducasse, Alvin I. Goldman, Keith Gunderson, David Hume, John Locke, Alasdair MacIntyre, A.I. Melden, John Stuart Mill, D.F. Pears, Hilary Putnam, Anthony Quinton, Bertrand Russell, Michael Scriven, Sydney Shoemaker, P. F. Strawson, Richard Taylor, and others. This volume is a unique invitation to join a distinguished group of theorists as they tackle tough questions concerning the existence of universals, the nature of causation, understanding personal identity, the tangled web of free will, and the challenges posed by the advent of artificial intelligence. (shrink)

This paper argues that Nonreductive ethical naturalism is a viable approach to normative ethical theory. Central to Nonreductive ethical naturalism is the identification of moral properties with natural ones. Natural properties are objective and pertain to facts. It follows that moral properties are factual in nature. In the proposed theory pain and harm are the natural properties that are also moral in nature. Pain and harm are not identical. Pain is the chief indicator of harm. The concept of harm entails (...) injury. Injury to an individual is both a factual and moral issue. The well-being of individuals constitutes the foundation of morality. Consequently, that which runs counter to an individual's well-being is what we mean by evil. It follows that injury is evil and its intentional infliction upon other people is morally evil. The factual nature of ethical properties provides the basis for universal agreement on which forms of behavior are evil. As such, acceptance of this theory would go a long way in resolving many of the global problems that confront us all at the onset of the 2 1 s t century. (shrink)

The problem of universals, important in the history of philosophy, remains a crucial issue today not only for metaphysics, but also for the philosophy of science. This anthology offers a comprehensive presentation of twenty-eight analyses of the problem of universals. It opens with analyses presented by Plato and Aristotle and then provides selections from the views of the medieval scholars Abelard, Aquinas, Duns Scotus, and Ockham. It then traces the development of Western thought on this fundamental topic from the modern (...) through the contemporary period and includes the work of Kant, Hegel, Husserl, Heidegger, Russell, Quine, Strawson, Carnap, and Allaire. To aid the student in understanding these investigations into the nature of universals, each reading is preceded by a concise introduction by the editor. (shrink)

Name der Zeitschrift: Kierkegaard Studies Yearbook Jahrgang: 19 Heft: 1 Seiten: 167-186.

Recent data show that catastrophic events during one cell cycle can cause massive genome damage producing viable clones with unstable genomes. This is in contrast with the traditional view that tumorigenesis requires a long‐term process in which mutations gradually accumulate over decades. These sudden events are likely to result in a large increase in genomic diversity within a relatively short time, providing the opportunity for selective advantages to be gained by a subset of cells within a population. This genetic diversity (...) amplification, arising from a single aberrant cell cycle, may drive a population conversion from benign to malignant. However, there is likely a period of relative genome stability during the clonal expansion of tumors – this may provide an opportunity for therapeutic intervention, especially if mechanisms that limit tolerance of aneuploidy are exploited. (shrink)

Here we elucidate a paradox: how a single chemoattractant‐receptor system in two individuals is used for communication despite the seeming inevitability of self‐excitation. In the filamentous fungus Neurospora crassa, genetically identical cells that produce the same chemoattractant fuse via the homing of individual cell protrusions toward each other. This is achieved via a recently described “ping‐pong” pulsatile communication. Using a generic activator‐inhibitor model of excitable behavior, we demonstrate that the pulse exchange can be fully understood in terms of two excitable (...) systems locked into a stable oscillatory pattern of mutual excitation. The most puzzling properties of this communication are the sudden onset of oscillations with final amplitude, and the absence of seemingly inevitable self‐excitation. We show that these properties result directly from both the excitability threshold and refractory period characteristic of excitable systems. Our model suggests possible molecular mechanisms for the ping‐pong communication. (shrink)

In “The Responsibilities and Role of Business in Relation to Society,” Nien-hê Hsieh challenges Joseph Heath’s “market failure” or Paretian approach to business ethics by arguing for a “Back to Basics” approach. Here, I argue that two basics of Hsieh’s three-basics vision are flawed, because a. ordinary morality is in fact not sufficient for the adversarial realm of the market, and b. the ideal of a Pareto-optimal market economy with perfect competition does in fact provide an adequate basis for normative (...) rules against market failures. (shrink)

From pluralism to consensus on terms of reference for the philosophy of education -- Approaches to a philosophy of education in the Philippine setting -- A philosophy of education based on a hermeneutics of retrieval -- A philosophy of education based on a hermeneutics of retrieval, the immediate past -- A philosophy of education based on a hermeneutics of the present -- A philosophy of education based on a hermeneutics of the potential, the future -- Integration.